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Substitution matrices For DNA/Protein Sequences Alignment |
| Protein Residue | A | R | N | D | C | Q | E | G | H | I | L | K | M | F | P | S | T | W | Y | V | B | J | Z | X | * |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | 5 | -2 | -1 | -2 | -1 | -1 | -1 | 0 | -2 | -1 | -1 | -1 | -1 | -2 | -1 | 1 | 0 | -2 | -2 | 0 | -1 | -1 | -1 | -1 | -5 |
| R | -2 | 7 | 0 | -1 | -3 | 1 | 0 | -2 | 0 | -3 | -2 | 3 | -1 | -2 | -2 | -1 | -1 | -2 | -1 | -2 | -1 | -3 | 1 | -1 | -5 |
| N | -1 | 0 | 6 | 2 | -2 | 0 | 0 | 0 | 1 | -2 | -3 | 0 | -2 | -2 | -2 | 1 | 0 | -4 | -2 | -3 | 5 | -3 | 0 | -1 | -5 |
| D | -2 | -1 | 2 | 7 | -3 | 0 | 2 | -1 | 0 | -4 | -3 | 0 | -3 | -4 | -1 | 0 | -1 | -4 | -2 | -3 | 6 | -3 | 1 | -1 | -5 |
| C | -1 | -3 | -2 | -3 | 12 | -3 | -3 | -3 | -3 | -3 | -2 | -3 | -2 | -2 | -4 | -1 | -1 | -5 | -3 | -1 | -2 | -2 | -3 | -1 | -5 |
| Q | -1 | 1 | 0 | 0 | -3 | 6 | 2 | -2 | 1 | -2 | -2 | 1 | 0 | -4 | -1 | 0 | -1 | -2 | -1 | -3 | 0 | -2 | 4 | -1 | -5 |
| E | -1 | 0 | 0 | 2 | -3 | 2 | 6 | -2 | 0 | -3 | -2 | 1 | -2 | -3 | 0 | 0 | -1 | -3 | -2 | -3 | 1 | -3 | 5 | -1 | -5 |
| G | 0 | -2 | 0 | -1 | -3 | -2 | -2 | 7 | -2 | -4 | -3 | -2 | -2 | -3 | -2 | 0 | -2 | -2 | -3 | -3 | -1 | -4 | -2 | -1 | -5 |
| H | -2 | 0 | 1 | 0 | -3 | 1 | 0 | -2 | 10 | -3 | -2 | -1 | 0 | -2 | -2 | -1 | -2 | -3 | 2 | -3 | 0 | -2 | 0 | -1 | -5 |
| I | -1 | -3 | -2 | -4 | -3 | -2 | -3 | -4 | -3 | 5 | 2 | -3 | 2 | 0 | -2 | -2 | -1 | -2 | 0 | 3 | -3 | 4 | -3 | -1 | -5 |
| L | -1 | -2 | -3 | -3 | -2 | -2 | -2 | -3 | -2 | 2 | 5 | -3 | 2 | 1 | -3 | -3 | -1 | -2 | 0 | 1 | -3 | 4 | -2 | -1 | -5 |
| K | -1 | 3 | 0 | 0 | -3 | 1 | 1 | -2 | -1 | -3 | -3 | 5 | -1 | -3 | -1 | -1 | -1 | -2 | -1 | -2 | 0 | -3 | 1 | -1 | -5 |
| M | -1 | -1 | -2 | -3 | -2 | 0 | -2 | -2 | 0 | 2 | 2 | -1 | 6 | 0 | -2 | -2 | -1 | -2 | 0 | 1 | -2 | 2 | -1 | -1 | -5 |
| F | -2 | -2 | -2 | -4 | -2 | -4 | -3 | -3 | -2 | 0 | 1 | -3 | 0 | 8 | -3 | -2 | -1 | 1 | 3 | 0 | -3 | 1 | -3 | -1 | -5 |
| P | -1 | -2 | -2 | -1 | -4 | -1 | 0 | -2 | -2 | -2 | -3 | -1 | -2 | -3 | 9 | -1 | -1 | -3 | -3 | -3 | -2 | -3 | -1 | -1 | -5 |
| S | 1 | -1 | 1 | 0 | -1 | 0 | 0 | 0 | -1 | -2 | -3 | -1 | -2 | -2 | -1 | 4 | 2 | -4 | -2 | -1 | 0 | -2 | 0 | -1 | -5 |
| T | 0 | -1 | 0 | -1 | -1 | -1 | -1 | -2 | -2 | -1 | -1 | -1 | -1 | -1 | -1 | 2 | 5 | -3 | -1 | 0 | 0 | -1 | -1 | -1 | -5 |
| W | -2 | -2 | -4 | -4 | -5 | -2 | -3 | -2 | -3 | -2 | -2 | -2 | -2 | 1 | -3 | -4 | -3 | 15 | 3 | -3 | -4 | -2 | -2 | -1 | -5 |
| Y | -2 | -1 | -2 | -2 | -3 | -1 | -2 | -3 | 2 | 0 | 0 | -1 | 0 | 3 | -3 | -2 | -1 | 3 | 8 | -1 | -2 | 0 | -2 | -1 | -5 |
| V | 0 | -2 | -3 | -3 | -1 | -3 | -3 | -3 | -3 | 3 | 1 | -2 | 1 | 0 | -3 | -1 | 0 | -3 | -1 | 5 | -3 | 2 | -3 | -1 | -5 |
| B | -1 | -1 | 5 | 6 | -2 | 0 | 1 | -1 | 0 | -3 | -3 | 0 | -2 | -3 | -2 | 0 | 0 | -4 | -2 | -3 | 5 | -3 | 1 | -1 | -5 |
| J | -1 | -3 | -3 | -3 | -2 | -2 | -3 | -4 | -2 | 4 | 4 | -3 | 2 | 1 | -3 | -2 | -1 | -2 | 0 | 2 | -3 | 4 | -2 | -1 | -5 |
| Z | -1 | 1 | 0 | 1 | -3 | 4 | 5 | -2 | 0 | -3 | -2 | 1 | -1 | -3 | -1 | 0 | -1 | -2 | -2 | -3 | 1 | -2 | 5 | -1 | -5 |
| X | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -5 |
| * | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | 1 |
| Protein Residue | A | R | N | D | C | Q | E | G | H | I | L | K | M | F | P | S | T | W | Y | V | B | J | Z | X | * |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | 5 | -2 | -1 | -2 | -1 | -1 | -1 | 0 | -2 | -1 | -2 | -1 | -1 | -3 | -1 | 1 | 0 | -3 | -2 | 0 | -2 | -2 | -1 | -1 | -5 |
| R | -2 | 7 | -1 | -2 | -4 | 1 | 0 | -3 | 0 | -4 | -3 | 3 | -2 | -3 | -3 | -1 | -1 | -3 | -1 | -3 | -1 | -3 | 0 | -1 | -5 |
| N | -1 | -1 | 7 | 2 | -2 | 0 | 0 | 0 | 1 | -3 | -4 | 0 | -2 | -4 | -2 | 1 | 0 | -4 | -2 | -3 | 5 | -4 | 0 | -1 | -5 |
| D | -2 | -2 | 2 | 8 | -4 | 0 | 2 | -1 | -1 | -4 | -4 | -1 | -4 | -5 | -1 | 0 | -1 | -5 | -3 | -4 | 6 | -4 | 1 | -1 | -5 |
| C | -1 | -4 | -2 | -4 | 13 | -3 | -3 | -3 | -3 | -2 | -2 | -3 | -2 | -2 | -4 | -1 | -1 | -5 | -3 | -1 | -3 | -2 | -3 | -1 | -5 |
| Q | -1 | 1 | 0 | 0 | -3 | 7 | 2 | -2 | 1 | -3 | -2 | 2 | 0 | -4 | -1 | 0 | -1 | -1 | -1 | -3 | 0 | -3 | 4 | -1 | -5 |
| E | -1 | 0 | 0 | 2 | -3 | 2 | 6 | -3 | 0 | -4 | -3 | 1 | -2 | -3 | -1 | -1 | -1 | -3 | -2 | -3 | 1 | -3 | 5 | -1 | -5 |
| G | 0 | -3 | 0 | -1 | -3 | -2 | -3 | 8 | -2 | -4 | -4 | -2 | -3 | -4 | -2 | 0 | -2 | -3 | -3 | -4 | -1 | -4 | -2 | -1 | -5 |
| H | -2 | 0 | 1 | -1 | -3 | 1 | 0 | -2 | 10 | -4 | -3 | 0 | -1 | -1 | -2 | -1 | -2 | -3 | 2 | -4 | 0 | -3 | 0 | -1 | -5 |
| I | -1 | -4 | -3 | -4 | -2 | -3 | -4 | -4 | -4 | 5 | 2 | -3 | 2 | 0 | -3 | -3 | -1 | -3 | -1 | 4 | -4 | 4 | -3 | -1 | -5 |
| L | -2 | -3 | -4 | -4 | -2 | -2 | -3 | -4 | -3 | 2 | 5 | -3 | 3 | 1 | -4 | -3 | -1 | -2 | -1 | 1 | -4 | 4 | -3 | -1 | -5 |
| K | -1 | 3 | 0 | -1 | -3 | 2 | 1 | -2 | 0 | -3 | -3 | 6 | -2 | -4 | -1 | 0 | -1 | -3 | -2 | -3 | 0 | -3 | 1 | -1 | -5 |
| M | -1 | -2 | -2 | -4 | -2 | 0 | -2 | -3 | -1 | 2 | 3 | -2 | 7 | 0 | -3 | -2 | -1 | -1 | 0 | 1 | -3 | 2 | -1 | -1 | -5 |
| F | -3 | -3 | -4 | -5 | -2 | -4 | -3 | -4 | -1 | 0 | 1 | -4 | 0 | 8 | -4 | -3 | -2 | 1 | 4 | -1 | -4 | 1 | -4 | -1 | -5 |
| P | -1 | -3 | -2 | -1 | -4 | -1 | -1 | -2 | -2 | -3 | -4 | -1 | -3 | -4 | 10 | -1 | -1 | -4 | -3 | -3 | -2 | -3 | -1 | -1 | -5 |
| S | 1 | -1 | 1 | 0 | -1 | 0 | -1 | 0 | -1 | -3 | -3 | 0 | -2 | -3 | -1 | 5 | 2 | -4 | -2 | -2 | 0 | -3 | 0 | -1 | -5 |
| T | 0 | -1 | 0 | -1 | -1 | -1 | -1 | -2 | -2 | -1 | -1 | -1 | -1 | -2 | -1 | 2 | 5 | -3 | -2 | 0 | 0 | -1 | -1 | -1 | -5 |
| W | -3 | -3 | -4 | -5 | -5 | -1 | -3 | -3 | -3 | -3 | -2 | -3 | -1 | 1 | -4 | -4 | -3 | 15 | 2 | -3 | -5 | -2 | -2 | -1 | -5 |
| Y | -2 | -1 | -2 | -3 | -3 | -1 | -2 | -3 | 2 | -1 | -1 | -2 | 0 | 4 | -3 | -2 | -2 | 2 | 8 | -1 | -3 | -1 | -2 | -1 | -5 |
| V | 0 | -3 | -3 | -4 | -1 | -3 | -3 | -4 | -4 | 4 | 1 | -3 | 1 | -1 | -3 | -2 | 0 | -3 | -1 | 5 | -3 | 2 | -3 | -1 | -5 |
| B | -2 | -1 | 5 | 6 | -3 | 0 | 1 | -1 | 0 | -4 | -4 | 0 | -3 | -4 | -2 | 0 | 0 | -5 | -3 | -3 | 6 | -4 | 1 | -1 | -5 |
| J | -2 | -3 | -4 | -4 | -2 | -3 | -3 | -4 | -3 | 4 | 4 | -3 | 2 | 1 | -3 | -3 | -1 | -2 | -1 | 2 | -4 | 4 | -3 | -1 | -5 |
| Z | -1 | 0 | 0 | 1 | -3 | 4 | 5 | -2 | 0 | -3 | -3 | 1 | -1 | -4 | -1 | 0 | -1 | -2 | -2 | -3 | 1 | -3 | 5 | -1 | -5 |
| X | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -5 |
| * | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | -5 | 1 |
| Protein Residue | A | R | N | D | C | Q | E | G | H | I | L | K | M | F | P | S | T | W | Y | V | B | J | Z | X | * |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | 4 | -1 | -2 | -2 | 0 | -1 | -1 | 0 | -2 | -1 | -1 | -1 | -1 | -2 | -1 | 1 | 0 | -3 | -2 | 0 | -2 | -1 | -1 | -1 | -4 |
| R | -1 | 5 | 0 | -2 | -3 | 1 | 0 | -2 | 0 | -3 | -2 | 2 | -1 | -3 | -2 | -1 | -1 | -3 | -2 | -3 | -1 | -2 | 0 | -1 | -4 |
| N | -2 | 0 | 6 | 1 | -3 | 0 | 0 | 0 | 1 | -3 | -3 | 0 | -2 | -3 | -2 | 1 | 0 | -4 | -2 | -3 | 4 | -3 | 0 | -1 | -4 |
| D | -2 | -2 | 1 | 6 | -3 | 0 | 2 | -1 | -1 | -3 | -4 | -1 | -3 | -3 | -1 | 0 | -1 | -4 | -3 | -3 | 4 | -3 | 1 | -1 | -4 |
| C | 0 | -3 | -3 | -3 | 9 | -3 | -4 | -3 | -3 | -1 | -1 | -3 | -1 | -2 | -3 | -1 | -1 | -2 | -2 | -1 | -3 | -1 | -3 | -1 | -4 |
| Q | -1 | 1 | 0 | 0 | -3 | 5 | 2 | -2 | 0 | -3 | -2 | 1 | 0 | -3 | -1 | 0 | -1 | -2 | -1 | -2 | 0 | -2 | 4 | -1 | -4 |
| E | -1 | 0 | 0 | 2 | -4 | 2 | 5 | -2 | 0 | -3 | -3 | 1 | -2 | -3 | -1 | 0 | -1 | -3 | -2 | -2 | 1 | -3 | 4 | -1 | -4 |
| G | 0 | -2 | 0 | -1 | -3 | -2 | -2 | 6 | -2 | -4 | -4 | -2 | -3 | -3 | -2 | 0 | -2 | -2 | -3 | -3 | -1 | -4 | -2 | -1 | -4 |
| H | -2 | 0 | 1 | -1 | -3 | 0 | 0 | -2 | 8 | -3 | -3 | -1 | -2 | -1 | -2 | -1 | -2 | -2 | 2 | -3 | 0 | -3 | 0 | -1 | -4 |
| I | -1 | -3 | -3 | -3 | -1 | -3 | -3 | -4 | -3 | 4 | 2 | -3 | 1 | 0 | -3 | -2 | -1 | -3 | -1 | 3 | -3 | 3 | -3 | -1 | -4 |
| L | -1 | -2 | -3 | -4 | -1 | -2 | -3 | -4 | -3 | 2 | 4 | -2 | 2 | 0 | -3 | -2 | -1 | -2 | -1 | 1 | -4 | 3 | -3 | -1 | -4 |
| K | -1 | 2 | 0 | -1 | -3 | 1 | 1 | -2 | -1 | -3 | -2 | 5 | -1 | -3 | -1 | 0 | -1 | -3 | -2 | -2 | 0 | -3 | 1 | -1 | -4 |
| M | -1 | -1 | -2 | -3 | -1 | 0 | -2 | -3 | -2 | 1 | 2 | -1 | 5 | 0 | -2 | -1 | -1 | -1 | -1 | 1 | -3 | 2 | -1 | -1 | -4 |
| F | -2 | -3 | -3 | -3 | -2 | -3 | -3 | -3 | -1 | 0 | 0 | -3 | 0 | 6 | -4 | -2 | -2 | 1 | 3 | -1 | -3 | 0 | -3 | -1 | -4 |
| P | -1 | -2 | -2 | -1 | -3 | -1 | -1 | -2 | -2 | -3 | -3 | -1 | -2 | -4 | 7 | -1 | -1 | -4 | -3 | -2 | -2 | -3 | -1 | -1 | -4 |
| S | 1 | -1 | 1 | 0 | -1 | 0 | 0 | 0 | -1 | -2 | -2 | 0 | -1 | -2 | -1 | 4 | 1 | -3 | -2 | -2 | 0 | -2 | 0 | -1 | -4 |
| T | 0 | -1 | 0 | -1 | -1 | -1 | -1 | -2 | -2 | -1 | -1 | -1 | -1 | -2 | -1 | 1 | 5 | -2 | -2 | 0 | -1 | -1 | -1 | -1 | -4 |
| W | -3 | -3 | -4 | -4 | -2 | -2 | -3 | -2 | -2 | -3 | -2 | -3 | -1 | 1 | -4 | -3 | -2 | 11 | 2 | -3 | -4 | -2 | -2 | -1 | -4 |
| Y | -2 | -2 | -2 | -3 | -2 | -1 | -2 | -3 | 2 | -1 | -1 | -2 | -1 | 3 | -3 | -2 | -2 | 2 | 7 | -1 | -3 | -1 | -2 | -1 | -4 |
| V | 0 | -3 | -3 | -3 | -1 | -2 | -2 | -3 | -3 | 3 | 1 | -2 | 1 | -1 | -2 | -2 | 0 | -3 | -1 | 4 | -3 | 2 | -2 | -1 | -4 |
| B | -2 | -1 | 4 | 4 | -3 | 0 | 1 | -1 | 0 | -3 | -4 | 0 | -3 | -3 | -2 | 0 | -1 | -4 | -3 | -3 | 4 | -3 | 0 | -1 | -4 |
| J | -1 | -2 | -3 | -3 | -1 | -2 | -3 | -4 | -3 | 3 | 3 | -3 | 2 | 0 | -3 | -2 | -1 | -2 | -1 | 2 | -3 | 3 | -3 | -1 | -4 |
| Z | -1 | 0 | 0 | 1 | -3 | 4 | 4 | -2 | 0 | -3 | -3 | 1 | -1 | -3 | -1 | 0 | -1 | -2 | -2 | -2 | 0 | -3 | 4 | -1 | -4 |
| X | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -4 |
| * | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | -4 | 1 |
| Protein Residue | A | R | N | D | C | Q | E | G | H | I | L | K | M | F | P | S | T | W | Y | V | B | J | Z | X | * |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | 5 | -2 | -2 | -2 | -1 | -1 | -1 | 0 | -2 | -2 | -2 | -1 | -1 | -3 | -1 | 1 | 0 | -3 | -2 | 0 | -2 | -2 | -1 | -1 | -6 |
| R | -2 | 6 | -1 | -2 | -4 | 1 | -1 | -3 | 0 | -3 | -3 | 2 | -2 | -4 | -2 | -1 | -1 | -4 | -3 | -3 | -1 | -3 | 0 | -1 | -6 |
| N | -2 | -1 | 6 | 1 | -3 | 0 | -1 | -1 | 0 | -4 | -4 | 0 | -3 | -4 | -3 | 0 | 0 | -4 | -3 | -4 | 5 | -4 | 0 | -1 | -6 |
| D | -2 | -2 | 1 | 6 | -4 | -1 | 1 | -2 | -2 | -4 | -5 | -1 | -4 | -4 | -2 | -1 | -1 | -6 | -4 | -4 | 5 | -5 | 1 | -1 | -6 |
| C | -1 | -4 | -3 | -4 | 9 | -4 | -5 | -4 | -4 | -2 | -2 | -4 | -2 | -3 | -4 | -2 | -1 | -3 | -3 | -1 | -4 | -2 | -4 | -1 | -6 |
| Q | -1 | 1 | 0 | -1 | -4 | 6 | 2 | -2 | 1 | -3 | -3 | 1 | 0 | -4 | -2 | 0 | -1 | -3 | -2 | -3 | 0 | -3 | 4 | -1 | -6 |
| E | -1 | -1 | -1 | 1 | -5 | 2 | 6 | -3 | 0 | -4 | -4 | 1 | -2 | -4 | -2 | 0 | -1 | -4 | -3 | -3 | 1 | -4 | 5 | -1 | -6 |
| G | 0 | -3 | -1 | -2 | -4 | -2 | -3 | 6 | -3 | -5 | -4 | -2 | -4 | -4 | -3 | -1 | -2 | -4 | -4 | -4 | -1 | -5 | -3 | -1 | -6 |
| H | -2 | 0 | 0 | -2 | -4 | 1 | 0 | -3 | 8 | -4 | -3 | -1 | -2 | -2 | -3 | -1 | -2 | -3 | 2 | -4 | -1 | -4 | 0 | -1 | -6 |
| I | -2 | -3 | -4 | -4 | -2 | -3 | -4 | -5 | -4 | 5 | 1 | -3 | 1 | -1 | -4 | -3 | -1 | -3 | -2 | 3 | -4 | 3 | -4 | -1 | -6 |
| L | -2 | -3 | -4 | -5 | -2 | -3 | -4 | -4 | -3 | 1 | 4 | -3 | 2 | 0 | -3 | -3 | -2 | -2 | -2 | 1 | -4 | 3 | -3 | -1 | -6 |
| K | -1 | 2 | 0 | -1 | -4 | 1 | 1 | -2 | -1 | -3 | -3 | 5 | -2 | -4 | -1 | -1 | -1 | -4 | -3 | -3 | -1 | -3 | 1 | -1 | -6 |
| M | -1 | -2 | -3 | -4 | -2 | 0 | -2 | -4 | -2 | 1 | 2 | -2 | 6 | 0 | -3 | -2 | -1 | -2 | -2 | 1 | -3 | 2 | -1 | -1 | -6 |
| F | -3 | -4 | -4 | -4 | -3 | -4 | -4 | -4 | -2 | -1 | 0 | -4 | 0 | 6 | -4 | -3 | -2 | 0 | 3 | -1 | -4 | 0 | -4 | -1 | -6 |
| P | -1 | -2 | -3 | -2 | -4 | -2 | -2 | -3 | -3 | -4 | -3 | -1 | -3 | -4 | 8 | -1 | -2 | -5 | -4 | -3 | -2 | -4 | -2 | -1 | -6 |
| S | 1 | -1 | 0 | -1 | -2 | 0 | 0 | -1 | -1 | -3 | -3 | -1 | -2 | -3 | -1 | 5 | 1 | -4 | -2 | -2 | 0 | -3 | 0 | -1 | -6 |
| T | 0 | -1 | 0 | -1 | -1 | -1 | -1 | -2 | -2 | -1 | -2 | -1 | -1 | -2 | -2 | 1 | 5 | -4 | -2 | 0 | -1 | -1 | -1 | -1 | -6 |
| W | -3 | -4 | -4 | -6 | -3 | -3 | -4 | -4 | -3 | -3 | -2 | -4 | -2 | 0 | -5 | -4 | -4 | 11 | 2 | -3 | -5 | -3 | -3 | -1 | -6 |
| Y | -2 | -3 | -3 | -4 | -3 | -2 | -3 | -4 | 2 | -2 | -2 | -3 | -2 | 3 | -4 | -2 | -2 | 2 | 7 | -2 | -3 | -2 | -3 | -1 | -6 |
| V | 0 | -3 | -4 | -4 | -1 | -3 | -3 | -4 | -4 | 3 | 1 | -3 | 1 | -1 | -3 | -2 | 0 | -3 | -2 | 4 | -4 | 2 | -3 | -1 | -6 |
| B | -2 | -1 | 5 | 5 | -4 | 0 | 1 | -1 | -1 | -4 | -4 | -1 | -3 | -4 | -2 | 0 | -1 | -5 | -3 | -4 | 5 | -4 | 0 | -1 | -6 |
| J | -2 | -3 | -4 | -5 | -2 | -3 | -4 | -5 | -4 | 3 | 3 | -3 | 2 | 0 | -4 | -3 | -1 | -3 | -2 | 2 | -4 | 3 | -3 | -1 | -6 |
| Z | -1 | 0 | 0 | 1 | -4 | 4 | 5 | -3 | 0 | -4 | -3 | 1 | -1 | -4 | -2 | 0 | -1 | -3 | -3 | -3 | 0 | -3 | 5 | -1 | -6 |
| X | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -6 |
| * | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | 1 |
| Protein Residue | A | R | N | D | C | Q | E | G | H | I | L | K | M | F | P | S | T | W | Y | V | B | J | Z | X | * |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | 5 | -2 | -2 | -3 | -1 | -1 | -1 | 0 | -2 | -2 | -2 | -1 | -2 | -3 | -1 | 1 | 0 | -4 | -3 | -1 | -2 | -2 | -1 | -1 | -6 |
| R | -2 | 6 | -1 | -3 | -5 | 1 | -1 | -3 | 0 | -4 | -3 | 2 | -2 | -4 | -3 | -1 | -2 | -4 | -3 | -3 | -2 | -3 | 0 | -1 | -6 |
| N | -2 | -1 | 7 | 1 | -4 | 0 | -1 | -1 | 0 | -4 | -4 | 0 | -3 | -4 | -3 | 0 | 0 | -5 | -3 | -4 | 5 | -4 | -1 | -1 | -6 |
| D | -3 | -3 | 1 | 7 | -5 | -1 | 1 | -2 | -2 | -5 | -5 | -1 | -4 | -5 | -3 | -1 | -2 | -6 | -4 | -5 | 5 | -5 | 1 | -1 | -6 |
| C | -1 | -5 | -4 | -5 | 9 | -4 | -6 | -4 | -5 | -2 | -2 | -4 | -2 | -3 | -4 | -2 | -2 | -4 | -4 | -2 | -4 | -2 | -5 | -1 | -6 |
| Q | -1 | 1 | 0 | -1 | -4 | 7 | 2 | -3 | 1 | -4 | -3 | 1 | 0 | -4 | -2 | -1 | -1 | -3 | -3 | -3 | -1 | -3 | 5 | -1 | -6 |
| E | -1 | -1 | -1 | 1 | -6 | 2 | 6 | -3 | -1 | -4 | -4 | 0 | -3 | -5 | -2 | -1 | -1 | -5 | -4 | -3 | 1 | -4 | 5 | -1 | -6 |
| G | 0 | -3 | -1 | -2 | -4 | -3 | -3 | 6 | -3 | -5 | -5 | -2 | -4 | -5 | -3 | -1 | -3 | -4 | -5 | -5 | -2 | -5 | -3 | -1 | -6 |
| H | -2 | 0 | 0 | -2 | -5 | 1 | -1 | -3 | 8 | -4 | -4 | -1 | -3 | -2 | -3 | -2 | -2 | -3 | 1 | -4 | -1 | -4 | 0 | -1 | -6 |
| I | -2 | -4 | -4 | -5 | -2 | -4 | -4 | -5 | -4 | 5 | 1 | -4 | 1 | -1 | -4 | -3 | -1 | -4 | -2 | 3 | -5 | 3 | -4 | -1 | -6 |
| L | -2 | -3 | -4 | -5 | -2 | -3 | -4 | -5 | -4 | 1 | 5 | -3 | 2 | 0 | -4 | -3 | -2 | -3 | -2 | 0 | -5 | 4 | -4 | -1 | -6 |
| K | -1 | 2 | 0 | -1 | -4 | 1 | 0 | -2 | -1 | -4 | -3 | 6 | -2 | -4 | -2 | -1 | -1 | -5 | -3 | -3 | -1 | -3 | 1 | -1 | -6 |
| M | -2 | -2 | -3 | -4 | -2 | 0 | -3 | -4 | -3 | 1 | 2 | -2 | 7 | -1 | -3 | -2 | -1 | -2 | -2 | 0 | -4 | 2 | -2 | -1 | -6 |
| F | -3 | -4 | -4 | -5 | -3 | -4 | -5 | -5 | -2 | -1 | 0 | -4 | -1 | 7 | -4 | -3 | -3 | 0 | 3 | -2 | -4 | 0 | -4 | -1 | -6 |
| P | -1 | -3 | -3 | -3 | -4 | -2 | -2 | -3 | -3 | -4 | -4 | -2 | -3 | -4 | 8 | -2 | -2 | -5 | -4 | -3 | -3 | -4 | -2 | -1 | -6 |
| S | 1 | -1 | 0 | -1 | -2 | -1 | -1 | -1 | -2 | -3 | -3 | -1 | -2 | -3 | -2 | 5 | 1 | -4 | -3 | -2 | 0 | -3 | -1 | -1 | -6 |
| T | 0 | -2 | 0 | -2 | -2 | -1 | -1 | -3 | -2 | -1 | -2 | -1 | -1 | -3 | -2 | 1 | 6 | -4 | -2 | -1 | -1 | -2 | -1 | -1 | -6 |
| W | -4 | -4 | -5 | -6 | -4 | -3 | -5 | -4 | -3 | -4 | -3 | -5 | -2 | 0 | -5 | -4 | -4 | 11 | 2 | -3 | -6 | -3 | -4 | -1 | -6 |
| Y | -3 | -3 | -3 | -4 | -4 | -3 | -4 | -5 | 1 | -2 | -2 | -3 | -2 | 3 | -4 | -3 | -2 | 2 | 8 | -3 | -4 | -2 | -3 | -1 | -6 |
| V | -1 | -3 | -4 | -5 | -2 | -3 | -3 | -5 | -4 | 3 | 0 | -3 | 0 | -2 | -3 | -2 | -1 | -3 | -3 | 5 | -4 | 1 | -3 | -1 | -6 |
| B | -2 | -2 | 5 | 5 | -4 | -1 | 1 | -2 | -1 | -5 | -5 | -1 | -4 | -4 | -3 | 0 | -1 | -6 | -4 | -4 | 5 | -5 | 0 | -1 | -6 |
| J | -2 | -3 | -4 | -5 | -2 | -3 | -4 | -5 | -4 | 3 | 4 | -3 | 2 | 0 | -4 | -3 | -2 | -3 | -2 | 1 | -5 | 4 | -4 | -1 | -6 |
| Z | -1 | 0 | -1 | 1 | -5 | 5 | 5 | -3 | 0 | -4 | -4 | 1 | -2 | -4 | -2 | -1 | -1 | -4 | -3 | -3 | 0 | -4 | 5 | -1 | -6 |
| X | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -6 |
| * | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | -6 | 1 |
| Protein Residue | A | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | Y |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | 7 | -10 | -6 | -5 | -12 | -4 | -11 | -8 | -10 | -9 | -8 | -7 | -4 | -7 | -10 | -3 | -3 | -5 | -20 | -11 |
| C | -10 | 10 | -21 | -20 | -19 | -13 | -10 | -9 | -20 | -21 | -20 | -17 | -11 | -20 | -11 | -6 | -11 | -9 | -22 | -7 |
| D | -6 | -21 | 8 | 0 | -21 | -6 | -7 | -11 | -8 | -19 | -17 | -1 | -12 | -6 | -17 | -7 | -8 | -11 | -21 | -17 |
| E | -5 | -20 | 0 | 8 | -20 | -7 | -9 | -8 | -7 | -13 | -10 | -5 | -9 | -1 | -15 | -7 | -9 | -10 | -23 | -11 |
| F | -12 | -19 | -21 | -20 | 9 | -12 | -9 | -5 | -20 | -5 | -7 | -12 | -13 | -19 | -12 | -9 | -12 | -12 | -7 | -1 |
| G | -4 | -13 | -6 | -7 | -12 | 7 | -13 | -17 | -10 | -14 | -12 | -6 | -10 | -10 | -13 | -4 | -10 | -9 | -21 | -20 |
| H | -11 | -10 | -7 | -9 | -9 | -13 | 10 | -13 | -10 | -9 | -17 | -2 | -7 | -2 | -4 | -9 | -11 | -9 | -10 | -6 |
| I | -8 | -9 | -11 | -8 | -5 | -17 | -13 | 9 | -9 | -4 | -3 | -8 | -12 | -11 | -8 | -10 | -5 | -1 | -20 | -9 |
| K | -10 | -20 | -8 | -7 | -20 | -10 | -10 | -9 | 7 | -11 | -4 | -4 | -10 | -6 | -2 | -7 | -6 | -13 | -18 | -12 |
| L | -9 | -21 | -19 | -13 | -5 | -14 | -9 | -4 | -11 | 7 | -2 | -10 | -10 | -8 | -12 | -12 | -10 | -5 | -9 | -10 |
| M | -8 | -20 | -17 | -10 | -7 | -12 | -17 | -3 | -4 | -2 | 12 | -15 | -11 | -7 | -7 | -8 | -7 | -4 | -19 | -17 |
| N | -7 | -17 | -1 | -5 | -12 | -6 | -2 | -8 | -4 | -10 | -15 | 9 | -9 | -7 | -9 | -2 | -5 | -12 | -11 | -7 |
| P | -4 | -11 | -12 | -9 | -13 | -10 | -7 | -12 | -10 | -10 | -11 | -9 | 8 | -6 | -7 | -4 | -7 | -9 | -20 | -20 |
| Q | -7 | -20 | -6 | -1 | -19 | -10 | -2 | -11 | -6 | -8 | -7 | -7 | -6 | 9 | -4 | -8 | -9 | -10 | -19 | -18 |
| R | -10 | -11 | -17 | -15 | -12 | -13 | -4 | -8 | -2 | -12 | -7 | -9 | -7 | -4 | 9 | -6 | -10 | -11 | -5 | -14 |
| S | -3 | -6 | -7 | -7 | -9 | -4 | -9 | -10 | -7 | -12 | -8 | -2 | -4 | -8 | -6 | 7 | -2 | -10 | -8 | -10 |
| T | -3 | -11 | -8 | -9 | -12 | -10 | -11 | -5 | -6 | -10 | -7 | -5 | -7 | -9 | -10 | -2 | 8 | -6 | -19 | -9 |
| V | -5 | -9 | -11 | -10 | -12 | -9 | -9 | -1 | -13 | -5 | -4 | -12 | -9 | -10 | -11 | -10 | -6 | 8 | -22 | -10 |
| W | -20 | -22 | -21 | -23 | -7 | -21 | -10 | -20 | -18 | -9 | -19 | -11 | -20 | -19 | -5 | -8 | -19 | -22 | 13 | -8 |
| Y | -11 | -7 | -17 | -11 | -1 | -20 | -6 | -9 | -12 | -10 | -17 | -7 | -20 | -18 | -14 | -10 | -9 | -10 | -8 | 10 |
| Protein Residue | A | R | N | D | C | Q | E | G | H | I | L | K | M | F | P | S | T | W | Y | V | B | J | Z | X | * |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | 6 | -7 | -4 | -3 | -6 | -4 | -2 | -2 | -7 | -5 | -6 | -7 | -5 | -8 | -2 | 0 | -1 | -13 | -8 | -2 | -3 | -6 | -3 | -1 | -17 |
| R | -7 | 8 | -6 | -10 | -8 | -2 | -9 | -9 | -2 | -5 | -8 | 0 | -4 | -9 | -4 | -3 | -6 | -2 | -10 | -8 | -7 | -7 | -4 | -1 | -17 |
| N | -4 | -6 | 8 | 2 | -11 | -3 | -2 | -3 | 0 | -5 | -7 | -1 | -9 | -9 | -6 | 0 | -2 | -8 | -4 | -8 | 6 | -6 | -3 | -1 | -17 |
| D | -3 | -10 | 2 | 8 | -14 | -2 | 2 | -3 | -4 | -7 | -12 | -4 | -11 | -15 | -8 | -4 | -5 | -15 | -11 | -8 | 6 | -10 | 1 | -1 | -17 |
| C | -6 | -8 | -11 | -14 | 10 | -14 | -14 | -9 | -7 | -6 | -15 | -14 | -13 | -13 | -8 | -3 | -8 | -15 | -4 | -6 | -12 | -9 | -14 | -1 | -17 |
| Q | -4 | -2 | -3 | -2 | -14 | 8 | 1 | -7 | 1 | -8 | -5 | -3 | -4 | -13 | -3 | -5 | -5 | -13 | -12 | -7 | -3 | -5 | 6 | -1 | -17 |
| E | -2 | -9 | -2 | 2 | -14 | 1 | 8 | -4 | -5 | -5 | -9 | -4 | -7 | -14 | -5 | -4 | -6 | -17 | -8 | -6 | 1 | -7 | 6 | -1 | -17 |
| G | -2 | -9 | -3 | -3 | -9 | -7 | -4 | 6 | -9 | -11 | -10 | -7 | -8 | -9 | -6 | -2 | -6 | -15 | -14 | -5 | -3 | -10 | -5 | -1 | -17 |
| H | -7 | -2 | 0 | -4 | -7 | 1 | -5 | -9 | 9 | -9 | -6 | -6 | -10 | -6 | -4 | -6 | -7 | -7 | -3 | -6 | -1 | -7 | -1 | -1 | -17 |
| I | -5 | -5 | -5 | -7 | -6 | -8 | -5 | -11 | -9 | 8 | -1 | -6 | -1 | -2 | -8 | -7 | -2 | -14 | -6 | 2 | -6 | 5 | -6 | -1 | -17 |
| L | -6 | -8 | -7 | -12 | -15 | -5 | -9 | -10 | -6 | -1 | 7 | -8 | 1 | -3 | -7 | -8 | -7 | -6 | -7 | -2 | -9 | 6 | -7 | -1 | -17 |
| K | -7 | 0 | -1 | -4 | -14 | -3 | -4 | -7 | -6 | -6 | -8 | 7 | -2 | -14 | -6 | -4 | -3 | -12 | -9 | -9 | -2 | -7 | -4 | -1 | -17 |
| M | -5 | -4 | -9 | -11 | -13 | -4 | -7 | -8 | -10 | -1 | 1 | -2 | 11 | -4 | -8 | -5 | -4 | -13 | -11 | -1 | -10 | 0 | -5 | -1 | -17 |
| F | -8 | -9 | -9 | -15 | -13 | -13 | -14 | -9 | -6 | -2 | -3 | -14 | -4 | 9 | -10 | -6 | -9 | -4 | 2 | -8 | -10 | -2 | -13 | -1 | -17 |
| P | -2 | -4 | -6 | -8 | -8 | -3 | -5 | -6 | -4 | -8 | -7 | -6 | -8 | -10 | 8 | -2 | -4 | -14 | -13 | -6 | -7 | -7 | -4 | -1 | -17 |
| S | 0 | -3 | 0 | -4 | -3 | -5 | -4 | -2 | -6 | -7 | -8 | -4 | -5 | -6 | -2 | 6 | 0 | -5 | -7 | -6 | -1 | -8 | -5 | -1 | -17 |
| T | -1 | -6 | -2 | -5 | -8 | -5 | -6 | -6 | -7 | -2 | -7 | -3 | -4 | -9 | -4 | 0 | 7 | -13 | -6 | -3 | -3 | -5 | -6 | -1 | -17 |
| W | -13 | -2 | -8 | -15 | -15 | -13 | -17 | -15 | -7 | -14 | -6 | -12 | -13 | -4 | -14 | -5 | -13 | 13 | -5 | -15 | -10 | -7 | -14 | -1 | -17 |
| Y | -8 | -10 | -4 | -11 | -4 | -12 | -8 | -14 | -3 | -6 | -7 | -9 | -11 | 2 | -13 | -7 | -6 | -5 | 10 | -7 | -6 | -7 | -9 | -1 | -17 |
| V | -2 | -8 | -8 | -8 | -6 | -7 | -6 | -5 | -6 | 2 | -2 | -9 | -1 | -8 | -6 | -6 | -3 | -15 | -7 | 7 | -8 | 0 | -6 | -1 | -17 |
| B | -3 | -7 | 6 | 6 | -12 | -3 | 1 | -3 | -1 | -6 | -9 | -2 | -10 | -10 | -7 | -1 | -3 | -10 | -6 | -8 | 6 | -8 | 0 | -1 | -17 |
| J | -6 | -7 | -6 | -10 | -9 | -5 | -7 | -10 | -7 | 5 | 6 | -7 | 0 | -2 | -7 | -8 | -5 | -7 | -7 | 0 | -8 | 6 | -6 | -1 | -17 |
| Z | -3 | -4 | -3 | 1 | -14 | 6 | 6 | -5 | -1 | -6 | -7 | -4 | -5 | -13 | -4 | -5 | -6 | -14 | -9 | -6 | 0 | -6 | 6 | -1 | -17 |
| X | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -17 |
| * | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | -17 | 1 |
| Protein Residue | A | R | N | D | C | Q | E | G | H | I | L | K | M | F | P | S | T | W | Y | V | B | J | Z | X | * |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | 5 | -4 | -2 | -1 | -4 | -2 | -1 | 0 | -4 | -2 | -4 | -4 | -3 | -6 | 0 | 1 | 1 | -9 | -5 | -1 | -1 | -3 | -1 | -1 | -11 |
| R | -4 | 8 | -3 | -6 | -5 | 0 | -5 | -6 | 0 | -3 | -6 | 2 | -2 | -7 | -2 | -1 | -4 | 0 | -7 | -5 | -4 | -5 | -2 | -1 | -11 |
| N | -2 | -3 | 6 | 3 | -7 | -1 | 0 | -1 | 1 | -3 | -5 | 0 | -5 | -6 | -3 | 1 | 0 | -6 | -3 | -5 | 5 | -4 | -1 | -1 | -11 |
| D | -1 | -6 | 3 | 6 | -9 | 0 | 3 | -1 | -1 | -5 | -8 | -2 | -7 | -10 | -4 | -1 | -2 | -10 | -7 | -5 | 5 | -7 | 2 | -1 | -11 |
| C | -4 | -5 | -7 | -9 | 9 | -9 | -9 | -6 | -5 | -4 | -10 | -9 | -9 | -8 | -5 | -1 | -5 | -11 | -2 | -4 | -8 | -7 | -9 | -1 | -11 |
| Q | -2 | 0 | -1 | 0 | -9 | 7 | 2 | -4 | 2 | -5 | -3 | -1 | -2 | -9 | -1 | -3 | -3 | -8 | -8 | -4 | -1 | -3 | 5 | -1 | -11 |
| E | -1 | -5 | 0 | 3 | -9 | 2 | 6 | -2 | -2 | -4 | -6 | -2 | -4 | -9 | -3 | -2 | -3 | -11 | -6 | -4 | 2 | -5 | 5 | -1 | -11 |
| G | 0 | -6 | -1 | -1 | -6 | -4 | -2 | 6 | -6 | -6 | -7 | -5 | -6 | -7 | -3 | 0 | -3 | -10 | -9 | -3 | -1 | -7 | -3 | -1 | -11 |
| H | -4 | 0 | 1 | -1 | -5 | 2 | -2 | -6 | 8 | -6 | -4 | -3 | -6 | -4 | -2 | -3 | -4 | -5 | -1 | -4 | 0 | -4 | 1 | -1 | -11 |
| I | -2 | -3 | -3 | -5 | -4 | -5 | -4 | -6 | -6 | 7 | 1 | -4 | 1 | 0 | -5 | -4 | -1 | -9 | -4 | 3 | -4 | 4 | -4 | -1 | -11 |
| L | -4 | -6 | -5 | -8 | -10 | -3 | -6 | -7 | -4 | 1 | 6 | -5 | 2 | -1 | -5 | -6 | -4 | -4 | -4 | 0 | -6 | 5 | -4 | -1 | -11 |
| K | -4 | 2 | 0 | -2 | -9 | -1 | -2 | -5 | -3 | -4 | -5 | 6 | 0 | -9 | -4 | -2 | -1 | -7 | -7 | -6 | -1 | -5 | -2 | -1 | -11 |
| M | -3 | -2 | -5 | -7 | -9 | -2 | -4 | -6 | -6 | 1 | 2 | 0 | 10 | -2 | -5 | -3 | -2 | -8 | -7 | 0 | -6 | 2 | -3 | -1 | -11 |
| F | -6 | -7 | -6 | -10 | -8 | -9 | -9 | -7 | -4 | 0 | -1 | -9 | -2 | 8 | -7 | -4 | -6 | -2 | 4 | -5 | -7 | -1 | -9 | -1 | -11 |
| P | 0 | -2 | -3 | -4 | -5 | -1 | -3 | -3 | -2 | -5 | -5 | -4 | -5 | -7 | 7 | 0 | -2 | -9 | -9 | -3 | -4 | -5 | -2 | -1 | -11 |
| S | 1 | -1 | 1 | -1 | -1 | -3 | -2 | 0 | -3 | -4 | -6 | -2 | -3 | -4 | 0 | 5 | 2 | -3 | -5 | -3 | 0 | -5 | -2 | -1 | -11 |
| T | 1 | -4 | 0 | -2 | -5 | -3 | -3 | -3 | -4 | -1 | -4 | -1 | -2 | -6 | -2 | 2 | 6 | -8 | -4 | -1 | -1 | -3 | -3 | -1 | -11 |
| W | -9 | 0 | -6 | -10 | -11 | -8 | -11 | -10 | -5 | -9 | -4 | -7 | -8 | -2 | -9 | -3 | -8 | 13 | -3 | -10 | -7 | -5 | -10 | -1 | -11 |
| Y | -5 | -7 | -3 | -7 | -2 | -8 | -6 | -9 | -1 | -4 | -4 | -7 | -7 | 4 | -9 | -5 | -4 | -3 | 9 | -5 | -4 | -4 | -7 | -1 | -11 |
| V | -1 | -5 | -5 | -5 | -4 | -4 | -4 | -3 | -4 | 3 | 0 | -6 | 0 | -5 | -3 | -3 | -1 | -10 | -5 | 6 | -5 | 1 | -4 | -1 | -11 |
| B | -1 | -4 | 5 | 5 | -8 | -1 | 2 | -1 | 0 | -4 | -6 | -1 | -6 | -7 | -4 | 0 | -1 | -7 | -4 | -5 | 5 | -5 | 1 | -1 | -11 |
| J | -3 | -5 | -4 | -7 | -7 | -3 | -5 | -7 | -4 | 4 | 5 | -5 | 2 | -1 | -5 | -5 | -3 | -5 | -4 | 1 | -5 | 5 | -4 | -1 | -11 |
| Z | -1 | -2 | -1 | 2 | -9 | 5 | 5 | -3 | 1 | -4 | -4 | -2 | -3 | -9 | -2 | -2 | -3 | -10 | -7 | -4 | 1 | -4 | 5 | -1 | -11 |
| X | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -11 |
| * | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | -11 | 1 |
| Protein Residue | A | B | C | D | E | F | G | H | I | K | L | M | N | P | Q | R | S | T | V | W | X | Y | Z | * |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | 3 | 0 | -3 | 0 | 0 | -4 | 1 | -3 | -1 | -2 | -3 | -2 | -1 | 1 | -1 | -3 | 1 | 1 | 0 | -7 | -1 | -4 | -1 | -8 |
| B | 0 | 4 | -6 | 4 | 3 | -5 | 0 | 1 | -3 | 0 | -4 | -4 | 3 | -2 | 0 | -2 | 0 | 0 | -3 | -6 | -1 | -3 | 2 | -8 |
| C | -3 | -6 | 9 | -7 | -7 | -6 | -4 | -4 | -3 | -7 | -7 | -6 | -5 | -4 | -7 | -4 | 0 | -3 | -3 | -8 | -4 | -1 | -7 | -8 |
| D | 0 | 4 | -7 | 5 | 3 | -7 | 0 | 0 | -3 | -1 | -5 | -4 | 2 | -3 | 1 | -3 | 0 | -1 | -3 | -8 | -2 | -5 | 3 | -8 |
| E | 0 | 3 | -7 | 3 | 5 | -7 | -1 | -1 | -3 | -1 | -4 | -3 | 1 | -2 | 2 | -3 | -1 | -2 | -3 | -8 | -1 | -5 | 4 | -8 |
| F | -4 | -5 | -6 | -7 | -7 | 8 | -5 | -3 | 0 | -7 | 0 | -1 | -4 | -5 | -6 | -5 | -3 | -4 | -3 | -1 | -3 | 4 | -6 | -8 |
| G | 1 | 0 | -4 | 0 | -1 | -5 | 5 | -4 | -4 | -3 | -5 | -4 | 0 | -2 | -3 | -4 | 1 | -1 | -2 | -8 | -2 | -6 | -2 | -8 |
| H | -3 | 1 | -4 | 0 | -1 | -3 | -4 | 7 | -4 | -2 | -3 | -4 | 2 | -1 | 3 | 1 | -2 | -3 | -3 | -3 | -2 | -1 | 1 | -8 |
| I | -1 | -3 | -3 | -3 | -3 | 0 | -4 | -4 | 6 | -3 | 1 | 1 | -2 | -3 | -3 | -2 | -2 | 0 | 3 | -6 | -1 | -2 | -3 | -8 |
| K | -2 | 0 | -7 | -1 | -1 | -7 | -3 | -2 | -3 | 5 | -4 | 0 | 1 | -2 | 0 | 2 | -1 | -1 | -4 | -5 | -2 | -5 | -1 | -8 |
| L | -3 | -4 | -7 | -5 | -4 | 0 | -5 | -3 | 1 | -4 | 5 | 3 | -4 | -3 | -2 | -4 | -4 | -3 | 1 | -3 | -2 | -2 | -3 | -8 |
| M | -2 | -4 | -6 | -4 | -3 | -1 | -4 | -4 | 1 | 0 | 3 | 8 | -3 | -3 | -1 | -1 | -2 | -1 | 1 | -6 | -2 | -4 | -2 | -8 |
| N | -1 | 3 | -5 | 2 | 1 | -4 | 0 | 2 | -2 | 1 | -4 | -3 | 4 | -2 | 0 | -1 | 1 | 0 | -3 | -4 | -1 | -2 | 0 | -8 |
| P | 1 | -2 | -4 | -3 | -2 | -5 | -2 | -1 | -3 | -2 | -3 | -3 | -2 | 6 | 0 | -1 | 1 | -1 | -2 | -7 | -2 | -6 | -1 | -8 |
| Q | -1 | 0 | -7 | 1 | 2 | -6 | -3 | 3 | -3 | 0 | -2 | -1 | 0 | 0 | 6 | 1 | -2 | -2 | -3 | -6 | -1 | -5 | 4 | -8 |
| R | -3 | -2 | -4 | -3 | -3 | -5 | -4 | 1 | -2 | 2 | -4 | -1 | -1 | -1 | 1 | 6 | -1 | -2 | -3 | 1 | -2 | -5 | -1 | -8 |
| S | 1 | 0 | 0 | 0 | -1 | -3 | 1 | -2 | -2 | -1 | -4 | -2 | 1 | 1 | -2 | -1 | 3 | 2 | -2 | -2 | -1 | -3 | -1 | -8 |
| T | 1 | 0 | -3 | -1 | -2 | -4 | -1 | -3 | 0 | -1 | -3 | -1 | 0 | -1 | -2 | -2 | 2 | 4 | 0 | -6 | -1 | -3 | -2 | -8 |
| V | 0 | -3 | -3 | -3 | -3 | -3 | -2 | -3 | 3 | -4 | 1 | 1 | -3 | -2 | -3 | -3 | -2 | 0 | 5 | -8 | -1 | -3 | -3 | -8 |
| W | -7 | -6 | -8 | -8 | -8 | -1 | -8 | -3 | -6 | -5 | -3 | -6 | -4 | -7 | -6 | 1 | -2 | -6 | -8 | 12 | -5 | -2 | -7 | -8 |
| X | -1 | -1 | -4 | -2 | -1 | -3 | -2 | -2 | -1 | -2 | -2 | -2 | -1 | -2 | -1 | -2 | -1 | -1 | -1 | -5 | -2 | -3 | -1 | -8 |
| Y | -4 | -3 | -1 | -5 | -5 | 4 | -6 | -1 | -2 | -5 | -2 | -4 | -2 | -6 | -5 | -5 | -3 | -3 | -3 | -2 | -3 | 8 | -5 | -8 |
| Z | -1 | 2 | -7 | 3 | 4 | -6 | -2 | 1 | -3 | -1 | -3 | -2 | 0 | -1 | 4 | -1 | -1 | -2 | -3 | -7 | -1 | -5 | 4 | -8 |
| * | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | 1 |
| Protein Residue | A | R | N | D | C | Q | E | G | H | I | L | K | M | F | P | S | T | W | Y | V | B | J | Z | X | * |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | 2 | -2 | 0 | 0 | -2 | 0 | 0 | 1 | -1 | -1 | -2 | -1 | -1 | -3 | 1 | 1 | 1 | -6 | -3 | 0 | 0 | -1 | 0 | -1 | -8 |
| R | -2 | 6 | 0 | -1 | -4 | 1 | -1 | -3 | 2 | -2 | -3 | 3 | 0 | -4 | 0 | 0 | -1 | 2 | -4 | -2 | -1 | -3 | 0 | -1 | -8 |
| N | 0 | 0 | 2 | 2 | -4 | 1 | 1 | 0 | 2 | -2 | -3 | 1 | -2 | -3 | 0 | 1 | 0 | -4 | -2 | -2 | 2 | -3 | 1 | -1 | -8 |
| D | 0 | -1 | 2 | 4 | -5 | 2 | 3 | 1 | 1 | -2 | -4 | 0 | -3 | -6 | -1 | 0 | 0 | -7 | -4 | -2 | 3 | -3 | 3 | -1 | -8 |
| C | -2 | -4 | -4 | -5 | 12 | -5 | -5 | -3 | -3 | -2 | -6 | -5 | -5 | -4 | -3 | 0 | -2 | -8 | 0 | -2 | -4 | -5 | -5 | -1 | -8 |
| Q | 0 | 1 | 1 | 2 | -5 | 4 | 2 | -1 | 3 | -2 | -2 | 1 | -1 | -5 | 0 | -1 | -1 | -5 | -4 | -2 | 1 | -2 | 3 | -1 | -8 |
| E | 0 | -1 | 1 | 3 | -5 | 2 | 4 | 0 | 1 | -2 | -3 | 0 | -2 | -5 | -1 | 0 | 0 | -7 | -4 | -2 | 3 | -3 | 3 | -1 | -8 |
| G | 1 | -3 | 0 | 1 | -3 | -1 | 0 | 5 | -2 | -3 | -4 | -2 | -3 | -5 | 0 | 1 | 0 | -7 | -5 | -1 | 0 | -4 | 0 | -1 | -8 |
| H | -1 | 2 | 2 | 1 | -3 | 3 | 1 | -2 | 6 | -2 | -2 | 0 | -2 | -2 | 0 | -1 | -1 | -3 | 0 | -2 | 1 | -2 | 2 | -1 | -8 |
| I | -1 | -2 | -2 | -2 | -2 | -2 | -2 | -3 | -2 | 5 | 2 | -2 | 2 | 1 | -2 | -1 | 0 | -5 | -1 | 4 | -2 | 3 | -2 | -1 | -8 |
| L | -2 | -3 | -3 | -4 | -6 | -2 | -3 | -4 | -2 | 2 | 6 | -3 | 4 | 2 | -3 | -3 | -2 | -2 | -1 | 2 | -3 | 5 | -3 | -1 | -8 |
| K | -1 | 3 | 1 | 0 | -5 | 1 | 0 | -2 | 0 | -2 | -3 | 5 | 0 | -5 | -1 | 0 | 0 | -3 | -4 | -2 | 1 | -3 | 0 | -1 | -8 |
| M | -1 | 0 | -2 | -3 | -5 | -1 | -2 | -3 | -2 | 2 | 4 | 0 | 6 | 0 | -2 | -2 | -1 | -4 | -2 | 2 | -2 | 3 | -2 | -1 | -8 |
| F | -3 | -4 | -3 | -6 | -4 | -5 | -5 | -5 | -2 | 1 | 2 | -5 | 0 | 9 | -5 | -3 | -3 | 0 | 7 | -1 | -4 | 2 | -5 | -1 | -8 |
| P | 1 | 0 | 0 | -1 | -3 | 0 | -1 | 0 | 0 | -2 | -3 | -1 | -2 | -5 | 6 | 1 | 0 | -6 | -5 | -1 | -1 | -2 | 0 | -1 | -8 |
| S | 1 | 0 | 1 | 0 | 0 | -1 | 0 | 1 | -1 | -1 | -3 | 0 | -2 | -3 | 1 | 2 | 1 | -2 | -3 | -1 | 0 | -2 | 0 | -1 | -8 |
| T | 1 | -1 | 0 | 0 | -2 | -1 | 0 | 0 | -1 | 0 | -2 | 0 | -1 | -3 | 0 | 1 | 3 | -5 | -3 | 0 | 0 | -1 | -1 | -1 | -8 |
| W | -6 | 2 | -4 | -7 | -8 | -5 | -7 | -7 | -3 | -5 | -2 | -3 | -4 | 0 | -6 | -2 | -5 | 17 | 0 | -6 | -5 | -3 | -6 | -1 | -8 |
| Y | -3 | -4 | -2 | -4 | 0 | -4 | -4 | -5 | 0 | -1 | -1 | -4 | -2 | 7 | -5 | -3 | -3 | 0 | 10 | -2 | -3 | -1 | -4 | -1 | -8 |
| V | 0 | -2 | -2 | -2 | -2 | -2 | -2 | -1 | -2 | 4 | 2 | -2 | 2 | -1 | -1 | -1 | 0 | -6 | -2 | 4 | -2 | 2 | -2 | -1 | -8 |
| B | 0 | -1 | 2 | 3 | -4 | 1 | 3 | 0 | 1 | -2 | -3 | 1 | -2 | -4 | -1 | 0 | 0 | -5 | -3 | -2 | 3 | -3 | 2 | -1 | -8 |
| J | -1 | -3 | -3 | -3 | -5 | -2 | -3 | -4 | -2 | 3 | 5 | -3 | 3 | 2 | -2 | -2 | -1 | -3 | -1 | 2 | -3 | 5 | -2 | -1 | -8 |
| Z | 0 | 0 | 1 | 3 | -5 | 3 | 3 | 0 | 2 | -2 | -3 | 0 | -2 | -5 | 0 | 0 | -1 | -6 | -4 | -2 | 2 | -2 | 3 | -1 | -8 |
| X | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -1 | -8 |
| * | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | -8 | 1 |
| DNA Residue | A | C | G | T | N (Undefined) |
|---|---|---|---|---|---|
| A | 1 | -3 | -3 | -3 | 0 |
| C | -3 | 1 | -3 | -3 | 0 |
| G | -3 | -3 | 1 | -3 | 0 |
| T | -3 | -3 | -3 | 1 | 0 |
| N (Undefined) | 0 | 0 | 0 | 0 | 0 |
| DNA Residue | A | C | G | T |
|---|---|---|---|---|
| A | 1 | 0 | 0 | 0 |
| C | 0 | 1 | 0 | 0 |
| G | 0 | 0 | 1 | 0 |
| T | 0 | 0 | 0 | 1 |